{"id":27348,"date":"2025-06-25T14:34:37","date_gmt":"2025-06-25T14:34:37","guid":{"rendered":"https:\/\/www.neuraxpharm.com\/it\/?page_id=27348"},"modified":"2026-05-13T10:42:46","modified_gmt":"2026-05-13T10:42:46","slug":"dosaggio-e-somministrazione","status":"publish","type":"page","link":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/","title":{"rendered":"Dosaggio e somministrazione"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"27348\" class=\"elementor elementor-27348\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-73ab12f elementor-section-height-min-height elementor-section-items-bottom elementor-section-boxed elementor-section-height-default\" data-id=\"73ab12f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b0f6ce4\" data-id=\"b0f6ce4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-275767a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"275767a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-e62a7c9\" data-id=\"e62a7c9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1565aff elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1565aff\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9c6a7e1\" data-id=\"9c6a7e1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ae6d87d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ae6d87d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-46e9635\" data-id=\"46e9635\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f9d89e4 jet-breadcrumbs-align-left elementor-widget elementor-widget-jet-breadcrumbs\" data-id=\"f9d89e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"jet-breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-breadcrumbs jet-blocks\">\n\t\t<div class=\"jet-breadcrumbs\">\n\t\t<div class=\"jet-breadcrumbs__content\">\n\t\t<div class=\"jet-breadcrumbs__wrap\"><div class=\"jet-breadcrumbs__item\"><a href=\"https:\/\/www.neuraxpharm.com\/it\/\" class=\"jet-breadcrumbs__item-link is-home\" rel=\"home\" title=\"Home\">Home<\/a><\/div>\n\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db37d79 elementor-widget elementor-widget-text-editor\" data-id=\"db37d79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>BRIUMVI\u00ae viene somministrato come infusione di ~ 1 ora, ogni 24 settimane<sup>a<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7d08032 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7d08032\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-c11807b\" data-id=\"c11807b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-280aad3 elementor-widget elementor-widget-text-editor\" data-id=\"280aad3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dosaggio e somministrazione di BRIUMVI\u00ae<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1dcb0e elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"e1dcb0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"#dosaggio\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_2\" data-name=\"Capa 2\" viewBox=\"0 0 47.46 47.46\"><defs><style>      .cls-1 {        fill: #ffc72c;        stroke-width: 0px;      }    <\/style><\/defs><g id=\"PROVEN_EFFICACY\" data-name=\"PROVEN EFFICACY\"><g id=\"ICON_MORE\" data-name=\"ICON MORE\"><path class=\"cls-1\" d=\"M23.73,0C10.64,0,0,10.64,0,23.73s10.64,23.73,23.73,23.73,23.73-10.64,23.73-23.73S36.81,0,23.73,0ZM23.73,44.07c-11.21,0-20.34-9.12-20.34-20.34S12.51,3.39,23.73,3.39s20.34,9.12,20.34,20.34-9.12,20.34-20.34,20.34Z\"><\/path><path class=\"cls-1\" d=\"M33.33,22.03h-7.91v-7.91c0-.94-.76-1.69-1.69-1.69s-1.69.76-1.69,1.69v7.91h-7.91c-.94,0-1.69.76-1.69,1.69s.76,1.69,1.69,1.69h7.91v7.91c0,.94.76,1.69,1.69,1.69s1.69-.76,1.69-1.69v-7.91h7.91c.94,0,1.69-.76,1.69-1.69s-.76-1.69-1.69-1.69Z\"><\/path><\/g><\/g><\/svg>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-32dfb48\" data-id=\"32dfb48\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10e8247 elementor-widget elementor-widget-text-editor\" data-id=\"10e8247\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Valutazioni prima dell&#8217;infusione<br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09682fe elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"09682fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"#frequenza\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_2\" data-name=\"Capa 2\" viewBox=\"0 0 47.46 47.46\"><defs><style>      .cls-1 {        fill: #ffc72c;        stroke-width: 0px;      }    <\/style><\/defs><g id=\"PROVEN_EFFICACY\" data-name=\"PROVEN EFFICACY\"><g id=\"ICON_MORE\" data-name=\"ICON MORE\"><path class=\"cls-1\" d=\"M23.73,0C10.64,0,0,10.64,0,23.73s10.64,23.73,23.73,23.73,23.73-10.64,23.73-23.73S36.81,0,23.73,0ZM23.73,44.07c-11.21,0-20.34-9.12-20.34-20.34S12.51,3.39,23.73,3.39s20.34,9.12,20.34,20.34-9.12,20.34-20.34,20.34Z\"><\/path><path class=\"cls-1\" d=\"M33.33,22.03h-7.91v-7.91c0-.94-.76-1.69-1.69-1.69s-1.69.76-1.69,1.69v7.91h-7.91c-.94,0-1.69.76-1.69,1.69s.76,1.69,1.69,1.69h7.91v7.91c0,.94.76,1.69,1.69,1.69s1.69-.76,1.69-1.69v-7.91h7.91c.94,0,1.69-.76,1.69-1.69s-.76-1.69-1.69-1.69Z\"><\/path><\/g><\/g><\/svg>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-f03eca6\" data-id=\"f03eca6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a5b24d8 elementor-widget elementor-widget-text-editor\" data-id=\"a5b24d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Somministrazione e velocit\u00e0 di infusione<br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75c1c88 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"75c1c88\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"#gravita\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_2\" data-name=\"Capa 2\" viewBox=\"0 0 47.46 47.46\"><defs><style>      .cls-1 {        fill: #ffc72c;        stroke-width: 0px;      }    <\/style><\/defs><g id=\"PROVEN_EFFICACY\" data-name=\"PROVEN EFFICACY\"><g id=\"ICON_MORE\" data-name=\"ICON MORE\"><path class=\"cls-1\" d=\"M23.73,0C10.64,0,0,10.64,0,23.73s10.64,23.73,23.73,23.73,23.73-10.64,23.73-23.73S36.81,0,23.73,0ZM23.73,44.07c-11.21,0-20.34-9.12-20.34-20.34S12.51,3.39,23.73,3.39s20.34,9.12,20.34,20.34-9.12,20.34-20.34,20.34Z\"><\/path><path class=\"cls-1\" d=\"M33.33,22.03h-7.91v-7.91c0-.94-.76-1.69-1.69-1.69s-1.69.76-1.69,1.69v7.91h-7.91c-.94,0-1.69.76-1.69,1.69s.76,1.69,1.69,1.69h7.91v7.91c0,.94.76,1.69,1.69,1.69s1.69-.76,1.69-1.69v-7.91h7.91c.94,0,1.69-.76,1.69-1.69s-.76-1.69-1.69-1.69Z\"><\/path><\/g><\/g><\/svg>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-bf4f786\" data-id=\"bf4f786\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e9e98cc elementor-widget elementor-widget-text-editor\" data-id=\"e9e98cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Preparazione di BRIUMVI\u00ae per l&#8217;infusione<br \/><br \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-665a147 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"665a147\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<a class=\"elementor-icon\" href=\"#istruzioni\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_2\" data-name=\"Capa 2\" viewBox=\"0 0 47.46 47.46\"><defs><style>      .cls-1 {        fill: #ffc72c;        stroke-width: 0px;      }    <\/style><\/defs><g id=\"PROVEN_EFFICACY\" data-name=\"PROVEN EFFICACY\"><g id=\"ICON_MORE\" data-name=\"ICON MORE\"><path class=\"cls-1\" d=\"M23.73,0C10.64,0,0,10.64,0,23.73s10.64,23.73,23.73,23.73,23.73-10.64,23.73-23.73S36.81,0,23.73,0ZM23.73,44.07c-11.21,0-20.34-9.12-20.34-20.34S12.51,3.39,23.73,3.39s20.34,9.12,20.34,20.34-9.12,20.34-20.34,20.34Z\"><\/path><path class=\"cls-1\" d=\"M33.33,22.03h-7.91v-7.91c0-.94-.76-1.69-1.69-1.69s-1.69.76-1.69,1.69v7.91h-7.91c-.94,0-1.69.76-1.69,1.69s.76,1.69,1.69,1.69h7.91v7.91c0,.94.76,1.69,1.69,1.69s1.69-.76,1.69-1.69v-7.91h7.91c.94,0,1.69-.76,1.69-1.69s-.76-1.69-1.69-1.69Z\"><\/path><\/g><\/g><\/svg>\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f3aceae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f3aceae\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8e0b5a0\" data-id=\"8e0b5a0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fa1d99 elementor-widget elementor-widget-text-editor\" data-id=\"4fa1d99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<sup>a<\/sup>Dopo la dose iniziale. L&#8217;infusione del 1\u00b0 giorno \u00e8 di 150 mg in circa 4 ore; l&#8217;infusione del 15\u00b0 giorno \u00e8 di 450 mg in circa 1 ora; le infusioni successive sono di 450 mg in circa 1 ora, ogni 24 settimane. La durata dell&#8217;infusione pu\u00f2 essere pi\u00f9 lunga se l&#8217;infusione viene interrotta o rallentata.<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-878b7bb elementor-widget elementor-widget-menu-anchor\" data-id=\"878b7bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"dosaggio\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f2c13b1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f2c13b1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a00dbb5\" data-id=\"a00dbb5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5cd15f2 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5cd15f2\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-b0eb901\" data-id=\"b0eb901\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-16394f8 elementor-widget elementor-widget-text-editor\" data-id=\"16394f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tBRIUMVI\u00ae \u00e8 un&#8217;infusione endovenosa (IV) di 450 mg della durata di un&#8217;ora, somministrata ogni 24 settimane dopo la prima infusione.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-93c4e20 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"93c4e20\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-fe97b77\" data-id=\"fe97b77\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6302e23 elementor-widget elementor-widget-text-editor\" data-id=\"6302e23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>BRIUMVI\u00ae \u00e8 somministrato come infusione endovenosa nel modo seguente<sup>1<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b1696c6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b1696c6\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-3560c8b\" data-id=\"3560c8b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-59b7c08 elementor-widget elementor-widget-image\" data-id=\"59b7c08\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1423\" height=\"1823\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a.png\" class=\"attachment-full size-full wp-image-28958\" alt=\"\" srcset=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a.png 1423w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a-234x300.png 234w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a-799x1024.png 799w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a-768x984.png 768w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a-1199x1536.png 1199w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a-600x769.png 600w\" sizes=\"(max-width: 1423px) 100vw, 1423px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d1cb4cc\" data-id=\"d1cb4cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6344373 elementor-widget elementor-widget-image\" data-id=\"6344373\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1434\" height=\"1823\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b.png\" class=\"attachment-full size-full wp-image-28959\" alt=\"\" srcset=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b.png 1434w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b-236x300.png 236w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b-805x1024.png 805w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b-768x976.png 768w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b-1208x1536.png 1208w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064652\/briumvi-dosing-adm-img-1b-600x763.png 600w\" sizes=\"(max-width: 1434px) 100vw, 1434px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e9f0f84\" data-id=\"e9f0f84\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c0e5de6 elementor-widget elementor-widget-image\" data-id=\"c0e5de6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1462\" height=\"1881\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1.png\" class=\"attachment-full size-full wp-image-28960\" alt=\"\" srcset=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1.png 1462w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1-233x300.png 233w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1-796x1024.png 796w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1-768x988.png 768w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1-1194x1536.png 1194w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064656\/briumvi-dosing-adm-img-1c-1-600x772.png 600w\" sizes=\"(max-width: 1462px) 100vw, 1462px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-89f2bf9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89f2bf9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-53dbaf0\" data-id=\"53dbaf0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1aebf3 elementor-widget elementor-widget-text-editor\" data-id=\"d1aebf3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prima di ogni infusione, devono essere somministrate le due premedicazioni seguenti (per via orale, endovenosa, intramuscolare o sottocutanea) al fine di ridurre la frequenza e la severit\u00e0 delle IRR (per ulteriori indicazioni sulla riduzione delle IRR, vedere paragrafo 4.4):<\/p><p>\u2022 100 mg di metilprednisolone o 10-20 mg di desametasone (o equivalente) circa 30-60 minuti prima di ogni infusione;<\/p><p>\u2022 antistaminico (ad es. difenidramina) circa 30-60 minuti prima di ogni infusione.<\/p><p>Inoltre, si pu\u00f2 prendere in considerazione la premedicazione con un antipiretico (ad es. paracetamolo).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbc274d elementor-widget elementor-widget-text-editor\" data-id=\"dbc274d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tVideo di formazione sull\u2019infusione di BRIUMVI\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-628509e elementor-widget elementor-widget-video\" data-id=\"628509e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/13104218\/briumvi-12-5-2026-1.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-83aefd3 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"83aefd3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f470b77\" data-id=\"f470b77\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2def57 elementor-widget elementor-widget-text-editor\" data-id=\"b2def57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<sup>a<\/sup>Si deve mantenere un intervallo minimo di 5 mesi tra una dose e l&#8217;altra di ublituximab.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e7ce5fa elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7ce5fa\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4a1a125\" data-id=\"4a1a125\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-167921a elementor-widget elementor-widget-heading\" data-id=\"167921a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">95%<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1e2d549\" data-id=\"1e2d549\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-82fe350 elementor-widget elementor-widget-heading\" data-id=\"82fe350\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">di tutte le infusioni di BRIUMVI\u00ae della durata di 1 ora sono state completate in circa 1 ora senza interruzione negli studi clinici<sup>2,b<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b341ca elementor-widget elementor-widget-heading\" data-id=\"0b341ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><sup>b<\/sup>\u00b1 5 minuti<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1212fd3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1212fd3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d1c047e\" data-id=\"d1c047e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6ded45d elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6ded45d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-e69bdd6\" data-id=\"e69bdd6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9289bd2 elementor-widget elementor-widget-menu-anchor\" data-id=\"9289bd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"sullinfusione\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7ff6c3 elementor-widget elementor-widget-jet-video\" data-id=\"c7ff6c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"jet-video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-video jet-elements\">\n<div class=\"jet-video jet-video--fa5-compat jet-video-aspect-ratio jet-video-aspect-ratio--16-9\" data-settings=\"{&quot;lightbox&quot;:false,&quot;autoplay&quot;:false}\"><iframe class=\"jet-video-iframe\" allowfullscreen allow=\"autoplay;encrypted-media\" title=\"youtube Video Player\" data-lazy-load=\"https:\/\/www.youtube.com\/embed\/7KBxIJ-2UUQ?feature=oembed&amp;start&amp;end&amp;wmode=opaque&amp;autoplay=0&amp;loop=0&amp;controls=1&amp;mute=0&amp;rel=0&amp;modestbranding=0\"><\/iframe>\n<div class=\"jet-video__overlay jet-video__overlay--custom-bg\" style=\"background-image: url(https:\/\/i.ytimg.com\/vi_webp\/7KBxIJ-2UUQ\/maxresdefault.webp);\">\n<div class=\"jet-video__play-button\" role=\"button\" tabindex=\"0\" aria-label=\"Video play button\"><span class=\"jet-elements-icon jet-video__play-button-icon\"><i aria-hidden=\"true\" class=\"fas fa-play\"><\/i><\/span>\t<span class=\"elementor-screen-only\">Play Video<\/span>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26cfe1d elementor-widget elementor-widget-menu-anchor\" data-id=\"26cfe1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"frequenza\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-45cbae6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"45cbae6\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-77127c8\" data-id=\"77127c8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a573196 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a573196\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-1c67e23\" data-id=\"1c67e23\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-56d968f elementor-widget elementor-widget-text-editor\" data-id=\"56d968f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Per ridurre la frequenza e la gravit\u00e0 delle reazioni correlate all&#8217;infusione (IRR), BRIUMVI\u00ae richiede una premedicazione. A partire dalla terza infusione non \u00e8 necessaria una sorveglianza sistematica post-infusione.<sup>1,a<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a06c1b elementor-widget elementor-widget-menu-anchor\" data-id=\"1a06c1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"gravita\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-23a7bbb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"23a7bbb\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-3774aa5\" data-id=\"3774aa5\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a4a17d2 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a4a17d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"97\" height=\"97\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064657\/briumvi-premedication-icon-1.svg\" class=\"attachment-full size-full wp-image-28961\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Premedicazione<\/h3><p class=\"elementor-image-box-description\">Prima di ogni infusione devono essere somministrate le due seguenti premedicazioni (per via orale, endovenosa, intramuscolare o sottocutanea):\n\n<br><br>\n\u2022 100 mg di metilprednisolone o 10-20 mg di desametasone (o un equivalente) circa 30-60 minuti prima di ogni infusione;\n<br>\n\u2022 antistaminico (ad es. difenidramina) circa 30-60 minuti prima di ogni infusione.\n<br><br>\nInoltre, pu\u00f2 essere presa in considerazione la premedicazione con un antipiretico (ad esempio, paracetamolo).<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-cc32b7c\" data-id=\"cc32b7c\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e6e0818 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"e6e0818\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"97\" height=\"97\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064657\/briumvi-treatment-icon-1.svg\" class=\"attachment-full size-full wp-image-28962\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Trattamento<\/h3><p class=\"elementor-image-box-description\">\u2022 Infusione del 1\u00b0 giorno: 150 mg in circa 4 ore <sup>b<\/sup>\n<br><br>\n\u2022 Infusione del 15\u00b0 giorno: 450 mg in circa 1 ora<sup>b<\/sup>\n<br><br>\n\u2022 Infusioni successive (ogni 24 settimane dopo la dose iniziale): 450 mg in circa 1 ora<sup>b<\/sup> <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-70ee751\" data-id=\"70ee751\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31dc126 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"31dc126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"97\" height=\"97\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064658\/briumvi-surveillance-icon-1.svg\" class=\"attachment-full size-full wp-image-28963\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Monitoraggio post-infusione<\/h3><p class=\"elementor-image-box-description\">\u00c8 richiesto un monitoraggio post-infusione di 1 ora il 1\u00b0 e il 15\u00b0 giorno.\n<hr>\n\n<p style=\"font-size:13px;line-height:18px\">Le infusioni successive non richiedono un monitoraggio post-infusione, a meno che non siano state osservate reazioni correlate all'infusione e\/o ipersensibilit\u00e0. I medici devono informare i pazienti che le reazioni correlate all'infusione possono verificarsi fino a 24 ore dopo l'infusione.\n<br><br>\nPer le indicazioni relative alla posologia per i pazienti che manifestano sintomi di IRR, vedi la sezione <b>section 4.2<\/b> <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9703144 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9703144\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4c8dbfb\" data-id=\"4c8dbfb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8408202 elementor-widget elementor-widget-text-editor\" data-id=\"8408202\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<sup>a<\/sup> \u00c8 richiesto un monitoraggio successivo all&#8217;infusione se si sono osservate IRR e\/o ipersensibilit\u00e0 con infusioni precedenti.<br>\n<sup>b<\/sup> La durata dell&#8217;infusione pu\u00f2 essere pi\u00f9 lunga se l&#8217;infusione viene interrotta o rallentata.<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3f35cac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f35cac\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-510c102\" data-id=\"510c102\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-455f405 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"455f405\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-a4a3dda\" data-id=\"a4a3dda\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b7ef1d elementor-widget elementor-widget-text-editor\" data-id=\"3b7ef1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tPrima della somministrazione di BRIUMVI\u00ae, assicurarsi che siano state effettuate le opportune valutazioni.<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8159b34 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8159b34\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6c882ba\" data-id=\"6c882ba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1905bdf elementor-widget elementor-widget-image\" data-id=\"1905bdf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-contraindications-icon-1.svg\" class=\"attachment-full size-full wp-image-28964\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f98690e elementor-widget elementor-widget-text-editor\" data-id=\"f98690e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Controindicazioni\n<\/strong><\/h3>\n<ul>\n \t<li>Ipersensibilit\u00e0 al principio attivo o ad uno qualsiasi degli eccipienti elencati nel <span style=\"color: #009ca6;\"><a href=\"#\">paragrafo 6.1.<\/a>.<\/span><\/li>\n \t<li>Infezione attiva grave  (vedi <a href=\"#\"><span style=\"color: #009ca6;\">paragrafo 4.4<\/span><\/a>).<\/li>\n \t<li>Pazienti in stato di grave immunocompromissione (vedi <a href=\"#\"><span style=\"color: #009ca6;\">paragrafo 4.4<\/span><\/a>).<\/li>\n \t<li>Tumori maligni attivi noti<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9f2cec8\" data-id=\"9f2cec8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d89a8a elementor-widget elementor-widget-image\" data-id=\"0d89a8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-infusion-line-icon-1.svg\" class=\"attachment-full size-full wp-image-28965\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d70c7af elementor-widget elementor-widget-text-editor\" data-id=\"d70c7af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Valutazioni precedenti alla prima infusione di BRIUMVI\u00ae<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18e411b elementor-widget elementor-widget-toggle\" data-id=\"18e411b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2601\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2601\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Screening dell'epatite-B-Virus (HBV)<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2601\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2601\">\u2022 Lo screening dell&#8217;HBV deve essere effettuato in tutti i pazienti prima dell&#8217;inizio del trattamento, secondo le linee guida locali.\n\n\u2022 I pazienti con HBV attivo (cio\u00e8 un&#8217;infezione attiva confermata da risultati positivi per HBsAg e test anti HB) non devono essere trattati con ublituximab.\n\n\u2022 I pazienti con sierologia positiva (cio\u00e8 negativi per l&#8217;HBsAg e positivi per l&#8217;anticorpo core dell&#8217;HB (HBcAb +) o che sono portatori dell&#8217;HBV (positivi per l&#8217;antigene di superficie, HBsAg+) devono consultare gli esperti di malattie epatiche prima di iniziare il trattamento e devono essere monitorati e gestiti secondo gli standard medici locali per prevenire la riattivazione dell&#8217;epatite B.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2602\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2602\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Valutazione dello stato immunitario  <span>(compresi immunoglobuline, linfociti, neutrofili)<\/span><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2602\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2602\"><ul>\n \t<li>Si raccomanda di verificare lo stato immunitario del paziente (compresi immunoglobuline, linfociti, neutrofili) prima della somministrazione.\n<\/li>\n \t<li>I pazienti gravemente immunocompromessi (ad es. neutropenia o linfopenia significative) non devono essere trattati (<a href=\"#\"><span style=\"color: #009ca6;\">paragrafi  4.3 e 4.8<\/span><\/a> del the SmPC).<\/li>\n \t<li>La somministrazione deve essere ritardata nei pazienti con un&#8217;infezione attiva fino alla risoluzione dell&#8217;infezione.<\/li>\n<\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2603\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2603\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Revisione dello stato di immunizzazione<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2603\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2603\"><ul>\n \t<li>La sicurezza dell&#8217;immunizzazione con vaccini vivi o vivi-attenuati, durante o dopo la terapia, non \u00e8 stata studiata e la vaccinazione con vaccini vivi-attenuati o vivi non \u00e8 raccomandata durante il trattamento e non fino alla replezione delle cellule B (vedi <a href=\"#\"><span style=\"color: #009ca6;\">paragrafo \n 5.1<\/span><\/a> del SmPC).<\/li>\n \t<li>Tutte le vaccinazioni devono essere somministrate secondo le linee guida di immunizzazione almeno 4 settimane prima dell&#8217;inizio del trattamento per i vaccini vivi o vivi attenuati e, quando possibile, almeno 2 settimane prima dell&#8217;inizio del trattamento per i vaccini inattivati.<\/li>\n<\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2604\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2604\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Esclusione della gravidanza<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2604\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2604\"><ul>\n \t<li>Le donne in et\u00e0 fertile devono usare una contraccezione efficace mentre ricevono ublituximab e per almeno 4 mesi dopo l&#8217;ultima infusione (vedi <a href=\"#\"><span style=\"color: #009ca6;\">paragrafi 5.1 and 5.2<\/span><\/a> del SmPC).<\/li>\n \t<li>BRIUMVI\u00ae deve essere evitato durante la gravidanza, a meno che il potenziale beneficio per la madre non superi il rischio potenziale per il feto.\n\n<ul>\n \t<li>Nei neonati nati da madri esposte ad altri anticorpi anti-CD20 durante la gravidanza sono state segnalate deplezione transitoria delle cellule B periferiche e linfocitopenia.\n<\/li>\n \t<li>Nei neonati di madri trattate con ublituximab durante la gravidanza, i vaccini vivi o vivi-attenuati non devono essere somministrati prima che il recupero della conta delle cellule B sia stato confermato.<\/li>\n<\/ul>\n<\/li>\n<\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2605\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2605\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Allattamento al seno<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2605\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2605\">Non \u00e8 noto se ublituximab sia escreto nel latte materno. \u00c8 noto che le IgG umane vengono escrete nel latte materno nei primi giorni dopo la nascita, per poi diminuire a basse concentrazioni subito dopo; di conseguenza, non si pu\u00f2 escludere un rischio per il bambino allattato al seno durante questo breve periodo. In seguito, ublituximab potrebbe essere utilizzato durante l&#8217;allattamento se clinicamente necessario.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4184390 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4184390\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cf7adeb\" data-id=\"cf7adeb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd9de0a elementor-widget elementor-widget-image\" data-id=\"bd9de0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-polyvinyl-icon-1.svg\" class=\"attachment-full size-full wp-image-28966\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-620dc36 elementor-widget elementor-widget-text-editor\" data-id=\"620dc36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Valutazioni prima di ogni infusione di BRIUMVI\u00ae <\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b09648 elementor-widget elementor-widget-toggle\" data-id=\"6b09648\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1121\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1121\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Verificare lo stato immunitario del paziente<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1121\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1121\">Esclusione di un&#8217;infezione attiva, la somministrazione di BRIUMVI\u00ae deve essere ritardata nei pazienti con un&#8217;infezione attiva fino alla risoluzione dell&#8217;infezione.\nPrima di ogni infusione di BRIUMVI\u00ae determinare se c&#8217;\u00e8 un&#8217;infezione attiva. Nei pazienti con un&#8217;infezione attiva, la somministrazione deve essere ritardata fino alla risoluzione dell&#8217;infezione.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1122\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1122\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Esclusione della gravidanza<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1122\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1122\"><ul>\n \t<li>WLe donne in et\u00e0 fertile devono usare una contraccezione efficace mentre ricevono ublituximab e per almeno 4 mesi dopo l&#8217;ultima infusione (vedi <a href=\"#\"><span style=\"color: #009ca6;\">paragrafi 5.1 and 5.2<\/span><\/a> del SmPC).<\/li>\n \t<li>BRIUMVI\u00ae deve essere evitato durante la gravidanza, a meno che il potenziale beneficio per la madre non superi il rischio potenziale per il feto.\n\n<ul>\n \t<li>Nei neonati nati da madri esposte ad altri anticorpi anti-CD20 durante la gravidanza sono state segnalate deplezione transitoria delle cellule B periferiche e linfocitopenia.\n<\/li>\n \t<li>Nei neonati di madri trattate con ublituximab durante la gravidanza, i vaccini vivi o vivi-attenuati non devono essere somministrati prima che il recupero della conta delle cellule B sia stato confermato.<\/li>\n<\/ul>\n<\/li>\n<\/ul><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1123\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1123\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Per le neomamme: Allattamento al seno<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1123\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1123\">Non \u00e8 noto se ublituximab sia escreto nel latte umano. \u00c8 noto che le IgG umane vengono escrete nel latte materno nei primi giorni dopo la nascita, per poi diminuire a basse concentrazioni subito dopo; di conseguenza, non si pu\u00f2 escludere un rischio per il bambino allattato al seno durante questo breve periodo. In seguito, ublituximab potrebbe essere utilizzato durante l&#8217;allattamento se clinicamente necessario.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6e427ac\" data-id=\"6e427ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-539f11a elementor-widget elementor-widget-image\" data-id=\"539f11a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-pre-medication-icon-1.svg\" class=\"attachment-full size-full wp-image-28967\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-575deb6 elementor-widget elementor-widget-text-editor\" data-id=\"575deb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Premedicazione prima delle infusioni per attenuare le reazioni correlate all&#8217;infusione<br \/><\/strong><\/h3><p>100 mg di metilprednisolone o 10-20 mg di desametasone (o un equivalente) circa 30-60 minuti prima di ogni infusione di BRIUMVI\u00ae;Difenidramina circa 30-60 minuti prima di ogni infusione di BRIUMVI\u00ae;<\/p><ul><li>antistaminico (ad es. difenidramina) circa 30-60 minuti prima di ogni infusione.<\/li><li>Inoltre, pu\u00f2 essere presa in considerazione la premedicazione con un antipiretico (ad es. paracetamolo).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1aa9dc1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1aa9dc1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b1bf2d8\" data-id=\"b1bf2d8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c538ebe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c538ebe\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-619eb65 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile\" data-id=\"619eb65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1d9ba4f elementor-widget elementor-widget-text-editor\" data-id=\"1d9ba4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tComprendere il dosaggio e la velocit\u00e0 di infusione corretti per i pazienti<sup>1<\/sup>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-292e33b elementor-widget elementor-widget-image\" data-id=\"292e33b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"706\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-scaled.png\" class=\"attachment-full size-full wp-image-28968\" alt=\"\" srcset=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-scaled.png 2560w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-300x83.png 300w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-1024x283.png 1024w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-768x212.png 768w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-1536x424.png 1536w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-2048x565.png 2048w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064702\/briumvi-dosing-adm-img-4-2-1-600x166.png 600w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a108df3 elementor-widget elementor-widget-text-editor\" data-id=\"a108df3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\u2022 I pazienti trattati con BRIUMVI\u00ae devono essere osservati durante le infusioni per eventuali sintomi di IRR.\n\n\u2022 Inoltre, devono essere tenuti sotto osservazione per almeno 1 ora dopo il completamento delle prime due infusioni per eventuali sintomi di IRR.\n\n\u2022 Dalla terza infusione in poi, la sorveglianza post-infusione \u00e8 richiesta solo quando si sono verificate reazioni all&#8217;infusione e\/o ipersensibilit\u00e0 durante le infusioni precedenti.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bfb7d3 elementor-widget elementor-widget-text-editor\" data-id=\"1bfb7d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<sup>a<\/sup>La durata dell&#8217;infusione pu\u00f2 essere pi\u00f9 lunga se l&#8217;infusione viene interrotta o rallentata.\n<br>\n<sup>b<\/sup>La prima infusione successiva deve essere somministrata 24 settimane dopo la prima infusione. Tra una dose e l&#8217;altra di BRIUMVI\u00ae deve intercorrere un intervallo minimo di 5 mesi.\n<br>\n<sup>c<\/sup>Le soluzioni per infusione endovenosa sono preparate diluendo il medicinale in una sacca per infusione da 250 mL contenente cloruro di sodio 9 mg\/ml (0,9%) soluzione iniettabile, a una concentrazione finale di 0,6 mg\/mL per la prima infusione e di 1,8 mg\/mL per la seconda infusione e tutte le infusioni successive.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-607848c elementor-widget elementor-widget-menu-anchor\" data-id=\"607848c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"istruzioni\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b04a4f2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b04a4f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b82fe87 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b82fe87\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3e8db89\" data-id=\"3e8db89\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dee2d93 elementor-widget elementor-widget-heading\" data-id=\"dee2d93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Le istruzioni <span>complete sul dosaggio e sulla somministrazione,<\/span>  vedi le informazioni complete allegate sulla prescrizione.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c46ce44 elementor-align-justify elementor-widget elementor-widget-button\" data-id=\"c46ce44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xl\" href=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/48\/2025\/07\/30142003\/infusion-card-a5-italian-07-40.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"Capa_2\" data-name=\"Capa 2\" viewBox=\"0 0 49.36 49.36\"><defs><style>      .cls-1 {        fill: #ffc72c;        stroke-width: 0px;      }    <\/style><\/defs><g id=\"HOME\"><g id=\"DOWNLOAD_icon\" data-name=\"DOWNLOAD icon\"><path class=\"cls-1\" d=\"M20.32,37.27c2.41,2.41,6.32,2.41,8.73,0,0,0,0,0,0,0l6.6-6.6c.76-.84.7-2.14-.15-2.91-.78-.71-1.98-.71-2.76,0l-6.02,6.02V2.06c.01-1.14-.91-2.06-2.04-2.06h0c-1.14,0-2.06.92-2.06,2.06l-.02,31.69-5.99-5.98c-.8-.8-2.11-.8-2.91,0-.8.8-.8,2.11,0,2.91l6.6,6.6Z\"><\/path><path class=\"cls-1\" d=\"M47.31,32.91h0c-1.14,0-2.06.92-2.06,2.06v8.23c0,1.14-.92,2.06-2.06,2.06H6.17c-1.14,0-2.06-.92-2.06-2.06v-8.23c0-1.14-.92-2.06-2.06-2.06h0c-1.14,0-2.06.92-2.06,2.06v8.23c0,3.41,2.76,6.17,6.17,6.17h37.02c3.41,0,6.17-2.76,6.17-6.17v-8.23c0-1.14-.92-2.06-2.06-2.06Z\"><\/path><\/g><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Scarica la scheda con i dettagli per l'infusione<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-767dc5d\" data-id=\"767dc5d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c636c2 elementor-widget elementor-widget-image\" data-id=\"8c636c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1709\" height=\"1139\" src=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1.jpg\" class=\"attachment-full size-full wp-image-28970\" alt=\"\" srcset=\"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1.jpg 1709w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1-300x200.jpg 300w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1-1024x682.jpg 1024w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1-768x512.jpg 768w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1-1536x1024.jpg 1536w, https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064704\/briumvi-dosing-and-administration-img-1-1-600x400.jpg 600w\" sizes=\"(max-width: 1709px) 100vw, 1709px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8b2c2ac elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8b2c2ac\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-35c21c4\" data-id=\"35c21c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7684f42 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7684f42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a6cb02 elementor-widget elementor-widget-heading\" data-id=\"0a6cb02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Adeguamenti in caso di IRR<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e70b28a elementor-widget elementor-widget-toggle\" data-id=\"e70b28a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2421\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2421\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reazioni all'infusione pericolose per la vita<sup>1<\/sup><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2421\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2421\"><p>Se durante un&#8217;infusione si manifestano segni di una IRR pericolosa per la vita o invalidante, l&#8217;infusione deve essere interrotta immediatamente e il paziente deve ricevere un trattamento adeguato. In questi pazienti il trattamento deve essere interrotto in modo permanente (vedi paragrafo 4.4 del SmPC RCP).<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2422\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2422\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reazioni infusionali gravi<sup>1<\/sup><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2422\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2422\"><p>Se un paziente manifesta una IRR da lieve a moderata, la velocit\u00e0 di infusione deve essere ridotta alla met\u00e0 della velocit\u00e0 all&#8217;inizio dell&#8217;evento. Questa velocit\u00e0 ridotta deve essere mantenuta per almeno 30 minuti. Se la velocit\u00e0 ridotta \u00e8 tollerata, la velocit\u00e0 di infusione pu\u00f2 essere aumentata come descritto nella tabella delle velocit\u00e0 di infusione.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2423\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2423\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reazioni all'infusione da lievi a moderate<sup>1<\/sup><\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2423\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2423\">Se un paziente manifesta una IRR da lieve a moderata, la velocit\u00e0 di infusione deve essere ridotta alla met\u00e0 della velocit\u00e0 all&#8217;inizio dell&#8217;evento. Questa velocit\u00e0 ridotta deve essere mantenuta per almeno 30 minuti. Se la velocit\u00e0 ridotta \u00e8 tollerata, la velocit\u00e0 di infusione pu\u00f2 essere aumentata come descritto nella tabella posologica.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-04334fd elementor-widget elementor-widget-text-editor\" data-id=\"04334fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Se un paziente manifesta una IRR da lieve a moderata, la velocit\u00e0 di infusione deve essere ridotta alla met\u00e0 della velocit\u00e0 all&#8217;inizio dell&#8217;evento. Questa velocit\u00e0 ridotta deve essere mantenuta per almeno 30 minuti. Se la velocit\u00e0 ridotta \u00e8 tollerata, la velocit\u00e0 di infusione pu\u00f2 essere aumentata come descritto nella tabella posologica.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ebd68a5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ebd68a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bfefd8a elementor-widget elementor-widget-toggle\" data-id=\"bfefd8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2011\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2011\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Dosi ritardate o saltate<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2011\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2011\"><p>Se si salta un&#8217;infusione, questa deve essere somministrata il prima possibile; la somministrazione dopo una dose ritardata o saltata non deve attendere la dose successiva prevista. L&#8217;intervallo di trattamento di 24 settimane (con un minimo di 5 mesi) deve essere mantenuto tra le dosi.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2012\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2012\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Popolazioni speciali<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2012\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2012\"><p>Non si ritiene necessario alcun aggiustamento della dose nei pazienti di et\u00e0 superiore ai 55 anni o nei pazienti con insufficienza renale o epatica.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ac2e998 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ac2e998\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7120ba8\" data-id=\"7120ba8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-47ae090 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"47ae090\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-954d9f8\" data-id=\"954d9f8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a53638 elementor-widget elementor-widget-heading\" data-id=\"8a53638\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Preparazione di BRIUMVI\u00ae per l'infusione<sup>1<\/sup><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e28e74 elementor-widget elementor-widget-text-editor\" data-id=\"6e28e74\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Il prodotto deve essere diluito prima della somministrazione ed \u00e8 destinato esclusivamente all&#8217;uso singolo.\n<\/li>\n \t<li>BRIUMVI\u00ae deve essere preparato da un operatore sanitario utilizzando una tecnica asettica.\n<\/li>\n \t<li>La soluzione per la somministrazione endovenosa viene preparata diluendo il prodotto in una sacca per infusione contenente 250 ml di soluzione iniettabile isotonica di cloruro di sodio 9 mg\/ml (0,9%).<\/li>\n \t\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-29a3067\" data-id=\"29a3067\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-05df1d6 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"05df1d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/plugins\/elementor\/assets\/images\/placeholder.png\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9fdb072 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9fdb072\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a3d9f27\" data-id=\"a3d9f27\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d9e55cc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d9e55cc\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-61a2d44\" data-id=\"61a2d44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75ea1a2 elementor-widget elementor-widget-text-editor\" data-id=\"75ea1a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Preparazione della soluzione per la prima infusione\n<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ca03188 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ca03188\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-280fd89\" data-id=\"280fd89\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d2a64cd elementor-widget elementor-widget-text-editor\" data-id=\"d2a64cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>1<\/span><br>\nPreparare una sacca per infusione contenente 250 ml di soluzione iniettabile di cloruro di sodio allo 0,9% e 1 fiala (150mg\/6ml) di BRIUMVI\u00ae.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-5d21cd6\" data-id=\"5d21cd6\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-332da55 elementor-widget elementor-widget-text-editor\" data-id=\"332da55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>2<\/span><br>\nPrelevare 6 ml di soluzione BRIUMVI\u00ae dalla fiala.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-c0f8953\" data-id=\"c0f8953\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0f68057 elementor-widget elementor-widget-text-editor\" data-id=\"0f68057\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>3<\/span><br>\nAggiungere 6 ml (150 mg) di BRIUMVI\u00ae in una sacca per infusione contenente 250 ml di soluzione iniettabile di cloruro di sodio allo 0,9%.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b0a5937 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b0a5937\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4e9ec36\" data-id=\"4e9ec36\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-77ba278 elementor-widget elementor-widget-text-editor\" data-id=\"77ba278\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Preparazione della soluzione per le infusione successive<\/strong><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-39bd11a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39bd11a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-75f9157\" data-id=\"75f9157\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0ff0262 elementor-widget elementor-widget-text-editor\" data-id=\"0ff0262\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>1<\/span><br>\nPreparare una sacca per infusione contenente 250 ml di soluzione iniettabile di cloruro di sodio allo 0,9% e 3 fiale (per un totale di 450 mg\/18 ml) di BRIUMVI\u00ae.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-acf3441\" data-id=\"acf3441\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90ba0de elementor-widget elementor-widget-text-editor\" data-id=\"90ba0de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>2<\/span><br>\nPrelevare 18 ml di soluzione di BRIUMVI\u00ae dalle fiale (6 ml per fiala).\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-d62df7d\" data-id=\"d62df7d\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8dda188 elementor-widget elementor-widget-text-editor\" data-id=\"8dda188\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span>3<\/span><br>\nAggiungere 18 ml (450 mg) di BRIUMVI\u00ae in una sacca per infusione contenente 250 ml di soluzione iniettabile di cloruro di sodio allo 0,9%.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-381ed90 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"381ed90\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0edca1c\" data-id=\"0edca1c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-8f82e28 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8f82e28\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-db0fd14\" data-id=\"db0fd14\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a7e305b elementor-widget elementor-widget-image\" data-id=\"a7e305b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-examination-icon-1.svg\" class=\"attachment-full size-full wp-image-28971\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e005a9 elementor-widget elementor-widget-text-editor\" data-id=\"1e005a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Valutazione della soluzione per infusione\n<\/strong><\/h3>\nBRIUMVI\u00ae \u00e8 una soluzione da limpida a opalescente, da incolore a leggermente gialla.\nNon utilizzare la soluzione se \u00e8 scolorita o se contiene particelle estranee.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-17c9ae4\" data-id=\"17c9ae4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-af2b727 elementor-widget elementor-widget-image\" data-id=\"af2b727\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-temperature-icon-1.svg\" class=\"attachment-full size-full wp-image-28972\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9dd28df elementor-widget elementor-widget-text-editor\" data-id=\"9dd28df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Portare la sacca di infusione a temperatura ambiente\n<\/strong><\/h3>\nPrima dell&#8217;inizio dell&#8217;infusione endovenosa, il contenuto della sacca di infusione deve essere a temperatura ambiente (20-25\u00b0C).\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-ccb36bb\" data-id=\"ccb36bb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3845022 elementor-widget elementor-widget-image\" data-id=\"3845022\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-infusion-line-icon-1.svg\" class=\"attachment-full size-full wp-image-28965\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-195bb3a elementor-widget elementor-widget-text-editor\" data-id=\"195bb3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Utilizzare una linea di infusione dedicata\n<\/strong><\/h3>\nDopo la diluizione, BRIUMVI\u00ae viene somministrato come infusione endovenosa attraverso una linea dedicata. Le infusioni di BRIUMVI\u00ae non devono essere somministrate come un push o bolo endovenoso.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a80e15c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a80e15c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-466d697\" data-id=\"466d697\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7624d2b elementor-widget elementor-widget-image\" data-id=\"7624d2b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-immediately-icon-1.svg\" class=\"attachment-full size-full wp-image-28973\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1a0229 elementor-widget elementor-widget-text-editor\" data-id=\"e1a0229\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Soluzione diluita per infusione endovenosa\n<\/strong><\/h3>\nDal punto di vista microbiologico, l&#8217;infusione preparata deve essere utilizzata immediatamente. Se non viene utilizzata immediatamente, i tempi e le condizioni di conservazione prima dell&#8217;uso sono di responsabilit\u00e0 dell&#8217;operatore e di norma non dovrebbero superare le 24 ore a 2-8\u00b0C e successivamente le 8 ore a temperatura ambiente, a meno che la diluizione non sia avvenuta in condizioni asettiche controllate e validate. Nel caso in cui un&#8217;infusione endovenosa non possa essere completata il giorno stesso, la soluzione rimanente deve essere scartata\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4d52982\" data-id=\"4d52982\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e658230 elementor-widget elementor-widget-image\" data-id=\"e658230\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-polyvinyl-icon-1.svg\" class=\"attachment-thumbnail size-thumbnail wp-image-28966\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01cf054 elementor-widget elementor-widget-text-editor\" data-id=\"01cf054\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Uso di sacche di cloruro di polivinile (PVC) o poliolefina (PO)<br \/><\/strong><\/h3><p>Non sono state osservate incompatibilit\u00e0 tra ublituximab e sacche in PVC o PO e set di somministrazione endovenosa.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-417bb7a\" data-id=\"417bb7a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db53edd elementor-widget elementor-widget-image\" data-id=\"db53edd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"123\" height=\"123\" src=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-storage-icon-1.svg\" class=\"attachment-thumbnail size-thumbnail wp-image-28974\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4707e52 elementor-widget elementor-widget-text-editor\" data-id=\"4707e52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Conservazione\n<\/strong><\/h3>\nConservare in frigorifero (2\u00b0C &#8211; 8\u00b0C). Non congelare. Conservare la fiala nella confezione esterna per proteggerla dalla luce.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c88e892 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c88e892\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-ceb2488\" data-id=\"ceb2488\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-87bc310 elementor-widget elementor-widget-text-editor\" data-id=\"87bc310\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t&nbsp;\n\n<style>\n    .reference-list {<br \/>      display: flex;<br \/>      flex-direction: column;<br \/>      gap: 1em;<br \/>    }<\/p>\n<p>    .reference-item {<br \/>      display: flex;<br \/>      align-items: flex-start;<br \/>    }<\/p>\n<p>    .reference-number {<br \/>      font-size: smaller;<br \/>      margin-right: 5px;<br \/>      vertical-align: super;<br \/>    }<\/p>\n<p>    .reference-text {<br \/>      text-align: left;<br \/>    }<\/p>\n<p>    .text-black-links a {<br \/>      color: black;<br \/>      text-decoration: none;<br \/>    }<\/p>\n<p>    .text-black-links a:hover {<br \/>      text-decoration: underline;<br \/>    }<br \/>  <\/style>\n\n&nbsp;\n<div class=\"reference-list text-black-links\">\n<div class=\"reference-item\"><strong>Riferimenti<\/strong><br>\n<span class=\"reference-number\"><sup>1<\/sup><\/span><span class=\"reference-text\">Neuraxpharm Pharmaceuticals S.L. BRIUMVI\u00ae, INN-ublituximab.Summary of product characteristics. European Medicines Agency.Disponibile su: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/BRIUMVI-epar-product-information_en.pdf (consultato il 17 novembre 2023)\n<\/span><\/div>\n\n<div class=\"reference-item\"><span class=\"reference-number\"><sup>2<\/sup><\/span><span class=\"reference-text\">Fox EJ, Steinman L, Hartung H-P, et al. Infusion-related Reactions (IRRs) with Ublituximab in Patients with Relapsing Multiple Sclerosis (RMS): Post Hoc Analyses from the Phase 3 ULTIMATE I and II Studies.\nPresentato al: 2022 American Academy of Neurology (AAN) Annual Meeting; 24-26 aprile 2022; Seattle, WA.\n<\/span><\/div>\n&nbsp;\n\n\n<\/div>\n&nbsp;\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9cc02ce elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9cc02ce\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6f8a3ab\" data-id=\"6f8a3ab\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-86871c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"86871c9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-effbbab\" data-id=\"effbbab\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Home BRIUMVI\u00ae viene somministrato come infusione di ~ 1 ora, ogni 24 settimanea Dosaggio e somministrazione di BRIUMVI\u00ae Valutazioni prima dell&#8217;infusione Somministrazione e velocit\u00e0 di infusione Preparazione di BRIUMVI\u00ae per l&#8217;infusione aDopo la dose iniziale. L&#8217;infusione del 1\u00b0 giorno \u00e8 di 150 mg in circa 4 ore; l&#8217;infusione del 15\u00b0 giorno \u00e8 di 450 mg [&hellip;]<\/p>\n","protected":false},"author":2493,"featured_media":0,"parent":27270,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-27348","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dosaggio e Somministrazione - Neuraxpharm Italia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dosaggio e somministrazione\" \/>\n<meta property=\"og:description\" content=\"Home BRIUMVI\u00ae viene somministrato come infusione di ~ 1 ora, ogni 24 settimanea Dosaggio e somministrazione di BRIUMVI\u00ae Valutazioni prima dell&#8217;infusione Somministrazione e velocit\u00e0 di infusione Preparazione di BRIUMVI\u00ae per l&#8217;infusione aDopo la dose iniziale. L&#8217;infusione del 1\u00b0 giorno \u00e8 di 150 mg in circa 4 ore; l&#8217;infusione del 15\u00b0 giorno \u00e8 di 450 mg [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/\" \/>\n<meta property=\"og:site_name\" content=\"Neuraxpharm Italia\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-13T10:42:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-dosing-adm-img-1a.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"16 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/\",\"url\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/\",\"name\":\"Dosaggio e Somministrazione - Neuraxpharm Italia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2026\\\/05\\\/briumvi-dosing-adm-img-1a.png\",\"datePublished\":\"2025-06-25T14:34:37+00:00\",\"dateModified\":\"2026-05-13T10:42:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/#primaryimage\",\"url\":\"https:\\\/\\\/static.neuraxpharm.com\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2026\\\/05\\\/06064648\\\/briumvi-dosing-adm-img-1a.png\",\"contentUrl\":\"https:\\\/\\\/static.neuraxpharm.com\\\/wp-content\\\/uploads\\\/sites\\\/5\\\/2026\\\/05\\\/06064648\\\/briumvi-dosing-adm-img-1a.png\",\"width\":1423,\"height\":1823},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/dosaggio-e-somministrazione\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portafoglio\",\"item\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sclerosi multipla Briumvi\",\"item\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/portafoglio\\\/sclerosi-multipla\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Dosaggio e somministrazione\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/#website\",\"url\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/\",\"name\":\"Neuraxpharm Italia\",\"description\":\"A European Leader for the CNS products\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.neuraxpharm.com\\\/it\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Dosaggio e Somministrazione - Neuraxpharm Italia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione","og_locale":"it_IT","og_type":"article","og_title":"Dosaggio e somministrazione","og_description":"Home BRIUMVI\u00ae viene somministrato come infusione di ~ 1 ora, ogni 24 settimanea Dosaggio e somministrazione di BRIUMVI\u00ae Valutazioni prima dell&#8217;infusione Somministrazione e velocit\u00e0 di infusione Preparazione di BRIUMVI\u00ae per l&#8217;infusione aDopo la dose iniziale. L&#8217;infusione del 1\u00b0 giorno \u00e8 di 150 mg in circa 4 ore; l&#8217;infusione del 15\u00b0 giorno \u00e8 di 450 mg [&hellip;]","og_url":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/","og_site_name":"Neuraxpharm Italia","article_modified_time":"2026-05-13T10:42:46+00:00","og_image":[{"url":"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-dosing-adm-img-1a.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Tempo di lettura stimato":"16 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/","url":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/","name":"Dosaggio e Somministrazione - Neuraxpharm Italia","isPartOf":{"@id":"https:\/\/www.neuraxpharm.com\/it\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/#primaryimage"},"image":{"@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/#primaryimage"},"thumbnailUrl":"https:\/\/www.neuraxpharm.com\/it\/wp-content\/uploads\/sites\/5\/2026\/05\/briumvi-dosing-adm-img-1a.png","datePublished":"2025-06-25T14:34:37+00:00","dateModified":"2026-05-13T10:42:46+00:00","breadcrumb":{"@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/#primaryimage","url":"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a.png","contentUrl":"https:\/\/static.neuraxpharm.com\/wp-content\/uploads\/sites\/5\/2026\/05\/06064648\/briumvi-dosing-adm-img-1a.png","width":1423,"height":1823},{"@type":"BreadcrumbList","@id":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/dosaggio-e-somministrazione\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portafoglio","item":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/"},{"@type":"ListItem","position":2,"name":"Sclerosi multipla Briumvi","item":"https:\/\/www.neuraxpharm.com\/it\/portafoglio\/sclerosi-multipla\/"},{"@type":"ListItem","position":3,"name":"Dosaggio e somministrazione"}]},{"@type":"WebSite","@id":"https:\/\/www.neuraxpharm.com\/it\/#website","url":"https:\/\/www.neuraxpharm.com\/it\/","name":"Neuraxpharm Italia","description":"A European Leader for the CNS products","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.neuraxpharm.com\/it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"}]}},"acf":[],"_links":{"self":[{"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/pages\/27348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/users\/2493"}],"replies":[{"embeddable":true,"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/comments?post=27348"}],"version-history":[{"count":22,"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/pages\/27348\/revisions"}],"predecessor-version":[{"id":29100,"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/pages\/27348\/revisions\/29100"}],"up":[{"embeddable":true,"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/pages\/27270"}],"wp:attachment":[{"href":"https:\/\/www.neuraxpharm.com\/it\/wp-json\/wp\/v2\/media?parent=27348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}